Part:BBa_K3030001

EAAT2-RNA

This basic part is EAAT2 RNA which can translate into EAAT2 protein that is a member of a family of the solute carrier family of proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. EAAT2 is responsible for over 90% of glutamate reuptake within the brain.

Sequence and Features

Assembly Compatibility:

• 10
  INCOMPATIBLE WITH RFC[10]

  Illegal PstI site found at 35
  Illegal PstI site found at 1329
  
• 12
  INCOMPATIBLE WITH RFC[12]

  Illegal PstI site found at 35
  Illegal PstI site found at 1329
  
• 21
  COMPATIBLE WITH RFC[21]
• 23
  INCOMPATIBLE WITH RFC[23]

  Illegal PstI site found at 35
  Illegal PstI site found at 1329
  
• 25
  INCOMPATIBLE WITH RFC[25]

  Illegal PstI site found at 35
  Illegal PstI site found at 1329
  
• 1000
  COMPATIBLE WITH RFC[1000]

Reference

Kanai, Y. and Hediger, M. A. (2003) ‘The glutamate and neutral amino acid transporter family : physiological and pharmacological implications’,European Journal of Pharmacology, 479(1–3), pp. 237–247. doi: 10.1016/j.ejphar.2003.08.073.